Sherlock Holmes, one of the most famous figures in all of literature, has inspired countless portrayals on both the big and small screen. Anyone who takes on the role of the world’s greatest detective indelibly leaves their mark on the character, as does everyone who plays his most famous cohort. Will Ferrell and John C. Reilly‘s contributions inÂ Holmes and Watson, however, promise to be a little bit different than those of anyone else who has played the pair of iconic sleuths. So when we got a chance to speak with them about the movie, we wanted to know what unique additions they wanted to make to the history of Arthur Conan Doyle’s characters. And we also wanted to find out if playing iconic detectives could help them solve some real cases.Our own Dan Casey sat down (in some very nice chairs) with Ferrell and Reilly, along with their co-stars Rebecca Hall and Lauren Lapkus, to ask them about their very different contributions to the lore of the characters. After truly getting into the minds of them, though, we also wanted to know if the actors had any insights into the famous, unsolved cases of D.B. Cooper, the Zodiac Killer, Amelia Earhart, Stonehenge, the Mary Celeste, and probably the most important mystery of them all…what was Lost really about?[brightcove video_id=”5981631548001″ brightcove_account_id=”3653334524001″ brightcove_player_id=”rJs2ZD8x”]We’re not totally sure whose reputation was damaged the most during that crime-solving session: Stonehenge as a tourist attraction or Jake Gyllenhaal the Zodiac Killer.Tough call, but that’s what happens when you ask the greatest detective ever and his friends to unearth some troubling answers. Even when Will Ferrell and John C. Reilly play Sherlock and Dr. Watson.Holmes and Watson comes to theaters on Christmas Day.